What, Where When, Why & How…
There was a thread on “Craigslist Arts Forum” “don’t ask, “Why?” beware asking, “How?” stick with, “What…?” “Why?” leads inexorably to paradox. “How?” traps us in a universe of causality. Both deny the ininite. “What…?” sharpens the scalpel of reality.”
Why?” is not a question without meaning, usefulness or danger as you assert.
“How ?” can be the answer to “Why”… although it can be a question on its own of great value.
“Where ?” & “When ?” you don’t even mention.
And the All important Question for You is “What?”
And to that your answer is that Nothing Exists.
So tell it to Einstein that his formula fails because it doesn’t deny the existence of Matter. 
Two things are infinite: the universe and human stupidity; and I’m not sure about the the universe. Albert Einstein